Midtown Manhattan, or simply Midtown, is an area of Manhattan, New York City home to world-famous commercial zones such as Rockefeller Center, Broadway, and Times Square. Midtown Manhattan is home to the city's tallest and most famous buildings such as the Empire State Building and Chrysler Building.

Midtown, along with "Uptown" and "Downtown", is one of the three major subdivisions of Manhattan (though "Uptown" and "Downtown" can also be used as adjectives or prepositions, and can take on completely different meanings in the other boroughs, whereas the term "Midtown" cannot) and can be understood as those parts of Manhattan in neither of these two other regions - that is, all areas between 14th Street and 59th Street, from the Hudson River to the East River, about five square miles or 12 km2. The core of Midtown Manhattan is from about 31st Street to 59th Street between Third and Ninth avenues, about two square miles (this is the area most commonly referred to as "Midtown.") The "Plaza District", a term used by Manhattan real estate professionals to denote the most expensive area of midtown from a commercial real estate perspective, lies between 42nd Street and 59th Street, from Third Avenue to Seventh Avenue, about a square kilometer or half a square mile.

As New York's largest central business district, Midtown Manhattan is indisputably the busiest single commercial district in the United States, and among the most intensely and diversely used pieces of real estate in the world. The great majority of New York City's skyscrapers, including its tallest hotels and apartment towers, lie within Midtown. More than 700,000 commuters work in its offices, hotels, and retail establishments; the area also hosts many tourists, visiting residents, and students. Some areas, especially Times Square and Fifth Avenue, have massive clusters of retail establishments. Sixth Avenue in Midtown holds the headquarters of three of the four major television networks, and is one of a few global centers of news and entertainment. It is also a growing center of finance, second in importance within the United States only to Downtown Manhattan's Financial District. Times Square is also the epicenter of American theater.

Midtown encompasses many neighborhoods including Hell's Kitchen and Chelsea on the West Side, and Murray Hill, Kips Bay, Turtle Bay, and Gramercy on the East Side. It is also sometimes broken into "Midtown East" and "Midtown West", or north and south as in the New York City Police Department's Midtown North and Midtown South precincts. A simplistic and by no means comprehensive list of the neighborhoods in the Midtown area is as follows:

Midtown also contains historical but defunct neighborhoods, such as the Ladie's Mile, along Fifth Avenue from 14th Street to 23rd Street and the Tenderloin, from 23rd Street to 42nd Street and Fifth Avenue to Seventh Avenue.

Other important sights in Midtown:

Important streets and thoroughfares in Midtown:

Midtown Manhattan has the headquarters of several companies, including 4Kids Entertainment, Barnes & Noble, Calvin Klein, Cantor Fitzgerald, CBS Corporation, Cushman & Wakefield, DC Comics, Deloitte, Foot Locker, Hess Corporation, Marsh & McLennan Companies, Marvel Entertainment, MetLife, Morgan Stanley, NBC Universal, The New York Times Company, Polo Ralph Lauren, Simon & Schuster, Six Flags, Thomson Reuters, Time Warner, and Viacom. The New York Institute of Finance is located in Midtown Manhattan.

Haier operates its United States offices in the Haier Building at 1356 Broadway; the building previously was a building of the Greenwich Savings Bank. Haier held the opening ceremony on March 4, 2002. Sumitomo Corporation operates its New York Office, the headquarters of the corporation's United States operations, at 600 Third Avenue, 10016 in the Murray Hill neighborhood. El Al's North American headquarters are in Midtown.

Prior to its dissolution American Overseas Airlines was headquartered in Midtown Manhattan. The MetLife Building, in previous eras, was the Pan Am Building and the headquarters of Pan American World Airways. In 1991 Pan Am decided that it would move its headquarters to the Miami area. When Pan Am shut down later in 1991, MetLife was headquartered in the Metropolitan Life Insurance Company Tower.

After Frank Borman became president of Eastern Airlines in 1975, he moved Eastern's headquarters from Rockefeller Center to Miami-Dade County, Florida.

In 1975 American Airlines was headquartered at 633 Third Avenue in Murray Hill. In 1978 American announced that it would move its headquarters to a site at Dallas/Fort Worth International Airport in 1979. The move affected up to 1,300 jobs. Mayor of New York City Ed Koch described this move as "betrayal" of New York City.

In 1975 Trans World Airlines was headquartered in Turtle Bay. TWA moved its headquarters from New York City to Mount Kisco, New York in the 1980s.

At one time Philip Morris Companies (now Altria Group) was headquartered in Midtown Manhattan. In 2003 Philip Morris announced that it would move its headquarters from New York City to Virginia. The company said that it planned to keep around 750 employees in its former headquarters. Brendan McCormick, a spokesperson for Philip Morris, said that the company estimated that the move would save the company over $60 million each year.

Prior to itd dissolution Trans Caribbean Airways had its headquarters in Midtown Manhattan. Prior to its dissolution Central Park Media, an anime and manga distributor, was headquartered in Midtown Manhattan.

Several countries, The Bahamas, People's Republic of China, Costa Rica, Germany, Republic of Ireland, Israel, Jamaica, Japan, Luxembourg, Mexico, Morocco, Saudi Arabia, Singapore, South Africa, United Kingdom, Ukraine, have consulates-general in Midtown Manhattan accredited to the United States. In addition the Taipei Economic and Cultural Office of the Republic of China is in Midtown Manhattan.

The Puerto Rico Federal Affairs Administration operates its New York office on the 22nd floor at 135 West 50th Street.

The United States Postal Service operates the James A. Farley Post Office, New York City's main post office, in Midtown Manhattan. The post office stopped 24 hour service beginning on May 9, 2009 due to decreasing mail traffic.

The New York City Department of Education operates public schools in Midtown Manhattan.

The New York Public Library operates the Mid-Manhattan Library at 455 Fifth Avenue at 40th Street. The system also operates the 58th Street Branch Library at 127 East 58th Street, between Park Avenue and Lexington Avenue.

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