This article is about the neighborhood currently known as Little Italy in Lower Manhattan. For the neighborhood once known as Little Italy in Upper Manhattan, see Italian Harlem.

Little Italy is a neighborhood in lower Manhattan, New York City, once known for its large population of Italians.

Historically, Little Italy extend as far south as Bayard Street, as far north as Bleecker, as far west as Lafayette and as far east as the Bowery.

Much of the neighborhood has been absorbed by Chinatown, as immigrants from China and other East Asian countries moved to the area. The northern reaches of Little Italy, near Houston Street, ceased to be recognizably Italian, and eventually became the neighborhood known today as NoLIta, an abbreviation for North of Little Italy. Today, the section of Mulberry Street between Broome and Canal Streets, is all that is left of the old Italian neighborhood. The street is lined with some two-dozen Italian restaurants popular with tourists, and seemingly very few locals. Unlike Chinatown, which continues to expand in all directions with new immigrants, little remains of the original Little Italy.

The Feast of San Gennaro is a large street fair, lasting 11 days, that takes place every September along Mulberry Street between Houston and Mosco Streets.

Other Italian American neighborhoods in New York City include Little Italy of the Bronx (on Arthur Avenue, in the Fordham section of The Bronx); Bensonhurst, Brooklyn; Bay Ridge, Brooklyn; various neighborhoods in Brooklyn; Howard Beach, Queens; Ozone Park, Queens; Middle Village, Queens; Morris Park, the Bronx; Pelham Bay, Bronx, and the whole borough of Staten Island (with Rosebank being the first enclave).

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